Accumulation of an Endogenous Tryptophan-Derived Metabolite in Colorectal and Breast Cancers
Identifieur interne : 003216 ( Main/Exploration ); précédent : 003215; suivant : 003217Accumulation of an Endogenous Tryptophan-Derived Metabolite in Colorectal and Breast Cancers
Auteurs : Paolo Puccetti [Italie] ; Francesca Fallarino [Italie] ; Antoine Italiano [France] ; Isabelle Soubeyran [France] ; Gaetan Macgrogan [France] ; Marc Debled [France] ; Valerie Velasco [France] ; Dominique Bodet [France] ; Sandrine Eimer [France] ; Marc Veldhoen [Royaume-Uni] ; Georges C. Prendergast [États-Unis] ; Michael Platten [Allemagne] ; Alban Bessede [France] ; Gilles J. Guillemin [Australie]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Tryptophane, Tumeurs colorectales, Tumeurs du sein.
- Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Tryptophan.
- metabolism : Breast Neoplasms, Colorectal Neoplasms.
- Humans.
Abstract
Tumor immune escape mechanisms are being regarded as suitable targets for tumor therapy. Among these, tryptophan catabolism plays a central role in creating an immunosuppressive environment, leading to tolerance to potentially immunogenic tumor antigens. Tryptophan catabolism is initiated by either indoleamine 2,3-dioxygenase (IDO-1/-2) or tryptophan 2,3-dioxygenase 2 (TDO2), resulting in biostatic tryptophan starvation and
Url:
DOI: 10.1371/journal.pone.0122046
PubMed: 25881064
PubMed Central: 4400104
Affiliations:
- Allemagne, Australie, France, Italie, Royaume-Uni, États-Unis
- Aquitaine, Bade-Wurtemberg, District de Karlsruhe, Nouvelle-Aquitaine, Pennsylvanie
- Bordeaux, Heidelberg
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type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Debled, Marc" sort="Debled, Marc" uniqKey="Debled M" first="Marc" last="Debled">Marc Debled</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Medical Oncology, Institut Bergonié, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Oncology, Institut Bergonié, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Velasco, Valerie" sort="Velasco, Valerie" uniqKey="Velasco V" first="Valerie" last="Velasco">Valerie Velasco</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Medical Oncology, Institut Bergonié, Bordeaux, France</addr-line></nlm:aff><country 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Medicine, University of Perugia, Perugia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental Medicine, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Fallarino, Francesca" sort="Fallarino, Francesca" uniqKey="Fallarino F" first="Francesca" last="Fallarino">Francesca Fallarino</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Experimental Medicine, University of Perugia, Perugia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental Medicine, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Italiano, Antoine" sort="Italiano, Antoine" uniqKey="Italiano A" first="Antoine" last="Italiano">Antoine Italiano</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Medical Oncology, Institut Bergonié, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Oncology, Institut Bergonié, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Soubeyran, Isabelle" sort="Soubeyran, Isabelle" uniqKey="Soubeyran I" first="Isabelle" last="Soubeyran">Isabelle Soubeyran</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Medical Oncology, Institut Bergonié, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Oncology, Institut Bergonié, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Macgrogan, Gaetan" sort="Macgrogan, Gaetan" uniqKey="Macgrogan G" first="Gaetan" last="Macgrogan">Gaetan Macgrogan</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Medical Oncology, Institut Bergonié, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Oncology, Institut Bergonié, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Debled, Marc" sort="Debled, Marc" uniqKey="Debled M" first="Marc" last="Debled">Marc Debled</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Medical Oncology, Institut Bergonié, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Oncology, Institut Bergonié, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Velasco, Valerie" sort="Velasco, Valerie" uniqKey="Velasco V" first="Valerie" last="Velasco">Valerie Velasco</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Medical Oncology, Institut Bergonié, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Oncology, Institut Bergonié, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Bodet, Dominique" sort="Bodet, Dominique" uniqKey="Bodet D" first="Dominique" last="Bodet">Dominique Bodet</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>ImmuSmol, Pessac, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>ImmuSmol, Pessac</wicri:regionArea><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation></author><author><name sortKey="Eimer, Sandrine" sort="Eimer, Sandrine" uniqKey="Eimer S" first="Sandrine" last="Eimer">Sandrine Eimer</name><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>Histology and Molecular Pathology of Tumors Laboratory EA 2406, University Bordeaux Segalen, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Histology and Molecular Pathology of Tumors Laboratory EA 2406, University Bordeaux Segalen, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Veldhoen, Marc" sort="Veldhoen, Marc" uniqKey="Veldhoen M" first="Marc" last="Veldhoen">Marc Veldhoen</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Laboratory for Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Laboratory for Lymphocyte Signalling and Development, The Babraham Institute, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Prendergast, Georges C" sort="Prendergast, Georges C" uniqKey="Prendergast G" first="Georges C." last="Prendergast">Georges C. Prendergast</name><affiliation wicri:level="2"><nlm:aff id="aff006"><addr-line>Lankenau Institute for Medical Research, Wynnewood, Pennsylvania, United states of America</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Lankenau Institute for Medical Research, Wynnewood, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Platten, Michael" sort="Platten, Michael" uniqKey="Platten M" first="Michael" last="Platten">Michael Platten</name><affiliation wicri:level="3"><nlm:aff id="aff007"><addr-line>CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center, Heidelberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff008"><addr-line>Department of Neurooncology, University Hospital, Heidelberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurooncology, University Hospital, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Bessede, Alban" sort="Bessede, Alban" uniqKey="Bessede A" first="Alban" last="Bessede">Alban Bessede</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>ImmuSmol, Pessac, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>ImmuSmol, Pessac</wicri:regionArea><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation></author><author><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name><affiliation wicri:level="1"><nlm:aff id="aff009"><addr-line>Macquarie University, Faculty of Medicine, Neuroinflammation group, Sydney, New South Wales, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Macquarie University, Faculty of Medicine, Neuroinflammation group, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff010"><addr-line>Applied Neurosciences Program, Peter Duncan Neurosciences Research Unit, St Vincent’s Centre for Applied Medical Research, Darlinghurst, New South Wales, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Applied Neurosciences Program, Peter Duncan Neurosciences Research Unit, St Vincent’s Centre for Applied Medical Research, Darlinghurst, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Breast Neoplasms (metabolism)</term><term>Colorectal Neoplasms (metabolism)</term><term>Humans</term><term>Tryptophan (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term><term>Tryptophane (métabolisme)</term><term>Tumeurs colorectales (métabolisme)</term><term>Tumeurs du sein (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Tryptophan</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Breast Neoplasms</term><term>Colorectal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Tryptophane</term><term>Tumeurs colorectales</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Tumor immune escape mechanisms are being regarded as suitable targets for tumor therapy. Among these, tryptophan catabolism plays a central role in creating an immunosuppressive environment, leading to tolerance to potentially immunogenic tumor antigens. Tryptophan catabolism is initiated by either indoleamine 2,3-dioxygenase (IDO-1/-2) or tryptophan 2,3-dioxygenase 2 (TDO2), resulting in biostatic tryptophan starvation and <sc>l</sc>-kynurenine production, which participates in shaping the dynamic relationship of the host’s immune system with tumor cells. Current immunotherapy strategies include blockade of IDO-1/-2 or TDO2, to restore efficient antitumor responses. Patients who might benefit from this approach are currently identified based on expression analyses of IDO-1/-2 or TDO2 in tumor tissue and/or enzymatic activity assessed by kynurenine/tryptophan ratios in the serum. We developed a monoclonal antibody targeting <sc>l</sc>-kynurenine as an <italic>in situ</italic> biomarker of IDO-1/-2 or TDO2 activity. Using Tissue Micro Array technology and immunostaining, colorectal and breast cancer patients were phenotyped based on <sc>l</sc>-kynurenine production. In colorectal cancer <sc>l</sc>-kynurenine was not unequivocally associated with IDO-1 expression, suggesting that the mere expression of tryptophan catabolic enzymes is not sufficiently informative for optimal immunotherapy.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Pardoll, Dm" uniqKey="Pardoll D">DM Pardoll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Munn, Dh" uniqKey="Munn D">DH Munn</name></author><author><name sortKey="Mellor, Al" uniqKey="Mellor A">AL Mellor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stone, Tw" uniqKey="Stone T">TW Stone</name></author><author><name sortKey="Darlington, Lg" uniqKey="Darlington L">LG Darlington</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fallarino, F" uniqKey="Fallarino F">F Fallarino</name></author><author><name sortKey="Grohmann, U" uniqKey="Grohmann U">U 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T" uniqKey="Hara T">T Hara</name></author><author><name sortKey="Akimoto, H" uniqKey="Akimoto H">H Akimoto</name></author><author><name sortKey="Takikawa, O" uniqKey="Takikawa O">O Takikawa</name></author><author><name sortKey="Kawabe, T" uniqKey="Kawabe T">T Kawabe</name></author><author><name sortKey="Isobe, K" uniqKey="Isobe K">K Isobe</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Italie</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Aquitaine</li><li>Bade-Wurtemberg</li><li>District de Karlsruhe</li><li>Nouvelle-Aquitaine</li><li>Pennsylvanie</li></region><settlement><li>Bordeaux</li><li>Heidelberg</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Puccetti, Paolo" sort="Puccetti, Paolo" uniqKey="Puccetti P" first="Paolo" last="Puccetti">Paolo Puccetti</name></noRegion><name sortKey="Fallarino, Francesca" sort="Fallarino, Francesca" uniqKey="Fallarino F" first="Francesca" last="Fallarino">Francesca Fallarino</name></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Italiano, Antoine" sort="Italiano, Antoine" uniqKey="Italiano A" first="Antoine" last="Italiano">Antoine Italiano</name></region><name sortKey="Bessede, Alban" sort="Bessede, Alban" uniqKey="Bessede A" first="Alban" last="Bessede">Alban Bessede</name><name sortKey="Bodet, Dominique" sort="Bodet, Dominique" uniqKey="Bodet D" first="Dominique" last="Bodet">Dominique Bodet</name><name sortKey="Debled, Marc" sort="Debled, Marc" uniqKey="Debled M" first="Marc" last="Debled">Marc Debled</name><name sortKey="Eimer, Sandrine" sort="Eimer, Sandrine" uniqKey="Eimer S" first="Sandrine" last="Eimer">Sandrine Eimer</name><name sortKey="Macgrogan, Gaetan" sort="Macgrogan, Gaetan" uniqKey="Macgrogan G" first="Gaetan" last="Macgrogan">Gaetan Macgrogan</name><name sortKey="Soubeyran, Isabelle" sort="Soubeyran, Isabelle" uniqKey="Soubeyran I" first="Isabelle" last="Soubeyran">Isabelle Soubeyran</name><name sortKey="Velasco, Valerie" sort="Velasco, Valerie" uniqKey="Velasco V" first="Valerie" last="Velasco">Valerie Velasco</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Veldhoen, Marc" sort="Veldhoen, Marc" uniqKey="Veldhoen M" first="Marc" last="Veldhoen">Marc Veldhoen</name></noRegion></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Prendergast, Georges C" sort="Prendergast, Georges C" uniqKey="Prendergast G" first="Georges C." last="Prendergast">Georges C. Prendergast</name></region></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Platten, Michael" sort="Platten, Michael" uniqKey="Platten M" first="Michael" last="Platten">Michael Platten</name></region><name sortKey="Platten, Michael" sort="Platten, Michael" uniqKey="Platten M" first="Michael" last="Platten">Michael Platten</name></country><country name="Australie"><noRegion><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name></noRegion><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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